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Protein stability of p53 targets determines their temporal expression dynamics in response to p53 pulsing
In response to DNA damage, the transcription factor p53 accumulates in a series of pulses. While p53 dynamics play a critical role in regulating stress responses, how p53 pulsing affects target protein expression is not well understood. Recently, we showed that p53 pulses generate diversity in targe...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446860/ https://www.ncbi.nlm.nih.gov/pubmed/30745421 http://dx.doi.org/10.1083/jcb.201803063 |