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Targeting VE-PTP phosphatase protects the kidney from diabetic injury

Diabetic nephropathy is a leading cause of end-stage kidney failure. Reduced angiopoietin-TIE2 receptor tyrosine kinase signaling in the vasculature leads to increased vascular permeability, inflammation, and endothelial cell loss and is associated with the development of diabetic complications. Her...

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Detalles Bibliográficos
Autores principales: Carota, Isabel A., Kenig-Kozlovsky, Yael, Onay, Tuncer, Scott, Rizaldy, Thomson, Benjamin R., Souma, Tomokazu, Bartlett, Christina S., Li, Yanyang, Procissi, Daniele, Ramirez, Veronica, Yamaguchi, Shinji, Tarjus, Antoine, Tanna, Christine E., Li, Chengjin, Eremina, Vera, Vestweber, Dietmar, Oladipupo, Sunday S., Breyer, Matthew D., Quaggin, Susan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446875/
https://www.ncbi.nlm.nih.gov/pubmed/30886059
http://dx.doi.org/10.1084/jem.20180009