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Transcription is a major driving force for plastid genome instability in Arabidopsis
Though it is an essential process, transcription can be a source of genomic instability. For instance, it may generate RNA:DNA hybrids as the nascent transcript hybridizes with the complementary DNA template. These hybrids, called R-loops, act as a major cause of replication fork stalling and DNA br...
Autores principales: | Pérez Di Giorgio, Juliana Andrea, Lepage, Étienne, Tremblay-Belzile, Samuel, Truche, Sébastien, Loubert-Hudon, Audrey, Brisson, Normand |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447228/ https://www.ncbi.nlm.nih.gov/pubmed/30943245 http://dx.doi.org/10.1371/journal.pone.0214552 |
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