Structures of the wild-type MexAB–OprM tripartite pump reveal its complex formation and drug efflux mechanism

In Pseudomonas aeruginosa, MexAB–OprM plays a central role in multidrug resistance by ejecting various drug compounds, which is one of the causes of serious nosocomial infections. Although the structures of the components of MexAB–OprM have been solved individually by X-ray crystallography, no struc...

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Detalles Bibliográficos
Autores principales: Tsutsumi, Kenta, Yonehara, Ryo, Ishizaka-Ikeda, Etsuko, Miyazaki, Naoyuki, Maeda, Shintaro, Iwasaki, Kenji, Nakagawa, Atsushi, Yamashita, Eiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447562/
https://www.ncbi.nlm.nih.gov/pubmed/30944318
http://dx.doi.org/10.1038/s41467-019-09463-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447562/
https://www.ncbi.nlm.nih.gov/pubmed/30944318
http://dx.doi.org/10.1038/s41467-019-09463-9

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