Local Administration of GITR Agonistic Antibody Induces a Stronger Antitumor Immunity than Systemic Delivery

An anti-glucocorticoid induced TNF receptor (GITR) agonistic antibody (Ab) induces an antitumor immunity with both stimulation of effector T cells and inhibition of regulatory T cell activity. To enhance GITR Ab-mediated tumor immunity, we focused on the intratumoral route, since a tumor-localized h...

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Detalles Bibliográficos
Autores principales: Narumi, Kenta, Miyakawa, Reina, Shibasaki, Chihiro, Henmi, Marina, Mizoguchi, Yukihiro, Ueda, Ryosuke, Hashimoto, Hisayoshi, Hiraoka, Nobuyoshi, Yoshida, Teruhiko, Aoki, Kazunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447616/
https://www.ncbi.nlm.nih.gov/pubmed/30944344
http://dx.doi.org/10.1038/s41598-019-41724-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447616/
https://www.ncbi.nlm.nih.gov/pubmed/30944344
http://dx.doi.org/10.1038/s41598-019-41724-x

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