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New type of interaction between the SARAH domain of the tumour suppressor RASSF1A and its mitotic kinase Aurora A
The tumour suppressor protein RASSF1A is phosphorylated by Aurora A kinase, thereby impairing its tumour suppressor function. Consequently, inhibiting the interaction between Aurora A and RASSF1A may be used for anti-tumour therapy. We used recombinant variants of RASSF1A to map the sites of interac...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447619/ https://www.ncbi.nlm.nih.gov/pubmed/30944388 http://dx.doi.org/10.1038/s41598-019-41972-x |