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Surfactant Protein D Reverses the Gene Signature of Transepithelial HIV-1 Passage and Restricts the Viral Transfer Across the Vaginal Barrier

Effective prophylactic strategy against the current epidemic of sexually transmitted HIV-1 infection requires understanding of the innate gatekeeping mechanisms at the genital mucosa. Surfactant protein D (SP-D), a member of the collectin family of proteins naturally present in the vaginal tract, is...

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Detalles Bibliográficos
Autores principales: Pandit, Hrishikesh, Kale, Kavita, Yamamoto, Hidemi, Thakur, Gargi, Rokade, Sushama, Chakraborty, Payal, Vasudevan, Madavan, Kishore, Uday, Madan, Taruna, Fichorova, Raina Nakova
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447669/
https://www.ncbi.nlm.nih.gov/pubmed/30984160
http://dx.doi.org/10.3389/fimmu.2019.00264