The Antiviral Apparatus: STING and Oncolytic Virus Restriction

A network of pattern recognition receptors (PRRs) is responsible for the detection of invading viruses and acts as the trigger for the host antiviral response. Central to this apparatus is stimulator of interferon genes (STING), which functions as a node and integrator of detection signals. Owing to...

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Autores principales: Lee, Joel, Ghonime, Mohammed G., Wang, Ruoning, Cassady, Kevin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447737/
https://www.ncbi.nlm.nih.gov/pubmed/30989105
http://dx.doi.org/10.1016/j.omto.2019.02.002
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author Lee, Joel
Ghonime, Mohammed G.
Wang, Ruoning
Cassady, Kevin A.
author_facet Lee, Joel
Ghonime, Mohammed G.
Wang, Ruoning
Cassady, Kevin A.
author_sort Lee, Joel
collection PubMed
description A network of pattern recognition receptors (PRRs) is responsible for the detection of invading viruses and acts as the trigger for the host antiviral response. Central to this apparatus is stimulator of interferon genes (STING), which functions as a node and integrator of detection signals. Owing to its role in both intrinsic and adaptive immunity, STING has become a focus for researchers in the field of oncolytic virotherapy. In this review, we consider the function of the cGAS-STING axis and its regulation, both by cellular mechanisms and as a result of viral interference.
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spelling pubmed-64477372019-04-15 The Antiviral Apparatus: STING and Oncolytic Virus Restriction Lee, Joel Ghonime, Mohammed G. Wang, Ruoning Cassady, Kevin A. Mol Ther Oncolytics Article A network of pattern recognition receptors (PRRs) is responsible for the detection of invading viruses and acts as the trigger for the host antiviral response. Central to this apparatus is stimulator of interferon genes (STING), which functions as a node and integrator of detection signals. Owing to its role in both intrinsic and adaptive immunity, STING has become a focus for researchers in the field of oncolytic virotherapy. In this review, we consider the function of the cGAS-STING axis and its regulation, both by cellular mechanisms and as a result of viral interference. American Society of Gene & Cell Therapy 2019-03-20 /pmc/articles/PMC6447737/ /pubmed/30989105 http://dx.doi.org/10.1016/j.omto.2019.02.002 Text en © 2019. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Lee, Joel
Ghonime, Mohammed G.
Wang, Ruoning
Cassady, Kevin A.
The Antiviral Apparatus: STING and Oncolytic Virus Restriction
title The Antiviral Apparatus: STING and Oncolytic Virus Restriction
title_full The Antiviral Apparatus: STING and Oncolytic Virus Restriction
title_fullStr The Antiviral Apparatus: STING and Oncolytic Virus Restriction
title_full_unstemmed The Antiviral Apparatus: STING and Oncolytic Virus Restriction
title_short The Antiviral Apparatus: STING and Oncolytic Virus Restriction
title_sort antiviral apparatus: sting and oncolytic virus restriction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447737/
https://www.ncbi.nlm.nih.gov/pubmed/30989105
http://dx.doi.org/10.1016/j.omto.2019.02.002
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