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Rap1 signal modulators control the maintenance of hematopoietic progenitors in bone marrow and adult long‐term hematopoiesis

Adult long‐term hematopoiesis depends on sustaining hematopoietic stem/progenitor cells (HSPC) in bone marrow (BM) niches, where their balance of quiescence, self‐renewal, and hematopoietic differentiation is tightly regulated. Although various BM stroma cells that produce niche factors have been id...

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Detalles Bibliográficos
Autores principales: Imai, Takahiko, Tanaka, Hiroki, Hamazaki, Yoko, Minato, Nagahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447830/
https://www.ncbi.nlm.nih.gov/pubmed/30767320
http://dx.doi.org/10.1111/cas.13974