Programmed cell death ligand 1 disruption by clustered regularly interspaced short palindromic repeats/Cas9‐genome editing promotes antitumor immunity and suppresses ovarian cancer progression

Programmed cell death ligand 1 (PD‐L1) on tumor cells suppresses anti‐tumor immunity and has an unfavorable prognostic impact in ovarian cancer patients. We herein report the pathophysiological and therapeutic impacts of PD‐L1 disruption in ovarian cancer. PD‐L1 was genetically disrupted in the muri...

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Detalles Bibliográficos
Autores principales: Yahata, Tamaki, Mizoguchi, Mika, Kimura, Akihiko, Orimo, Takashi, Toujima, Saori, Kuninaka, Yumi, Nosaka, Mizuho, Ishida, Yuko, Sasaki, Izumi, Fukuda‐Ohta, Yuri, Hemmi, Hiroaki, Iwahashi, Naoyuki, Noguchi, Tomoko, Kaisho, Tsuneyasu, Kondo, Toshikazu, Ino, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447841/
https://www.ncbi.nlm.nih.gov/pubmed/30702189
http://dx.doi.org/10.1111/cas.13958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447841/
https://www.ncbi.nlm.nih.gov/pubmed/30702189
http://dx.doi.org/10.1111/cas.13958

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