The PI3K inhibitor buparlisib suppresses osteoclast formation and tumour cell growth in bone metastasis of lung cancer, as evidenced by multimodality molecular imaging

Non-small cell lung cancer (NSCLC) metastasis commonly occurs in bone, which often results in pathological fractures. Sustained phosphoinositide-3-kinase (PI3K) signalling promotes the growth of PI3K-dependent NSCLC and elevates osteoclastogenic potential. The present study investigated the effects...

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Detalles Bibliográficos
Autores principales: Wang, Shengfei, Niu, Xiaomin, Bao, Xiao, Wang, Qin, Zhang, Jianping, Lu, Shun, Wang, Yongjun, Xu, Ling, Wang, Mingwei, Zhang, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448067/
https://www.ncbi.nlm.nih.gov/pubmed/30896825
http://dx.doi.org/10.3892/or.2019.7080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448067/
https://www.ncbi.nlm.nih.gov/pubmed/30896825
http://dx.doi.org/10.3892/or.2019.7080

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