Cargando…

Targeting P16INK4A in uterine serous carcinoma through inhibition of histone demethylation

Uterine serous carcinoma (USC) is a subtype of endometrial cancer. Compared with endometrial endometroid carcinoma, the majority of USC cases are more aggressive. Cyclin-dependent kinase inhibitor 2A (P16INK4A) is a canonical tumor suppressor that blocks cell cycle progression; however, P16INK4A is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiao, Zhen, He, Yingying, Liu, Chongya, Xiang, Lin, Yi, Jingyan, Wang, Min, Shen, Tingting, Shen, Lanlin, Xue, Yijue, Shi, Hong, Liu, Pixu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448098/ https://www.ncbi.nlm.nih.gov/pubmed/30896884 http://dx.doi.org/10.3892/or.2019.7067

Ejemplares similares

MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer
por: Yi, Jingyan, et al.
Publicado: (2019)

Inhibition of SGK1 confers vulnerability to redox dysregulation in cervical cancer
por: Wang, Min, et al.
Publicado: (2019)

Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation
por: Dong, Cheng, et al.
Publicado: (2014)

BTF3 confers oncogenic activity in prostate cancer through transcriptional upregulation of Replication Factor C
por: Zhang, Yuan, et al.
Publicado: (2021)

Effect of ribose-glycated BSA on histone demethylation
por: Xi, Mengqi, et al.
Publicado: (2022)

Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation
por: Jiang, Yuhui, et al.
Publicado: (2015)

The SGK3-Catalase antioxidant signaling axis drives cervical cancer growth and therapy resistance
por: Wang, Min, et al.
Publicado: (2023)

Utility of p16INK4a expression for the interpretation of uterine cervical biopsies in Kenya
por: Muvunyi, Thierry Zawadi, et al.
Publicado: (2021)

KDM6B-mediated histone demethylation of LDHA promotes lung metastasis of osteosarcoma
por: Jiang, Yuhang, et al.
Publicado: (2021)

Promoter and histone methylation and p16(INK4A) gene expression in colon cancer
por: YORUKER, EBRU ESIN, et al.
Publicado: (2012)

Regulation of histone arginine methylation/demethylation by methylase and demethylase
por: Zhang, Jing, et al.
Publicado: (2019)

Primed histone demethylation regulates shoot regenerative competency
por: Ishihara, Hiroya, et al.
Publicado: (2019)

Epigenetic Regulation of Adipogenic Differentiation by Histone Lysine Demethylation
por: Nic-Can, Geovanny I., et al.
Publicado: (2019)

Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma
por: Hashizume, Rintaro, et al.
Publicado: (2014)

Calcitriol induces cell senescence of kidney cancer through JMJD3 mediated histone demethylation
por: Shen, Yongqing, et al.
Publicado: (2017)

LSD1 binds to HPV16 E7 and promotes the epithelial-mesenchymal transition in cervical cancer by demethylating histones at the Vimentin promoter
por: Liu, Yuan, et al.
Publicado: (2016)

The Utility of p16INK4a and Ki-67 as a Conjunctive Tool in Uterine Cervical Lesions
por: Lee, Sangho, et al.
Publicado: (2012)

LSD1: more than demethylation of histone lysine residues
por: Perillo, Bruno, et al.
Publicado: (2020)

The role of omentectomy in the surgical treatment of uterine serous carcinoma
por: Chen, Ming, et al.
Publicado: (2019)

Phenethyl Isothiocyanate Enhances the Cytotoxic Effects of PARP Inhibitors in High-Grade Serous Ovarian Cancer Cells
por: Jia, Yaxun, et al.
Publicado: (2022)

Suppression of Gluconeogenic Gene Expression by LSD1-Mediated Histone Demethylation
por: Pan, Dongning, et al.
Publicado: (2013)

Methylation and demethylation of DNA and histones in chromatin: the most complicated epigenetic marker
por: Youn, Hong-Duk
Publicado: (2017)

Pathogenesis and Clinical Management of Uterine Serous Carcinoma
por: Zhang, Li, et al.
Publicado: (2020)

Senescence delay and repression of p16(INK4a) by Lsh via recruitment of histone deacetylases in human diploid fibroblasts
por: Zhou, Rui, et al.
Publicado: (2009)

Gene expression fingerprint of uterine serous papillary carcinoma: identification of novel molecular markers for uterine serous cancer diagnosis and therapy
por: Santin, A D, et al.
Publicado: (2005)

A case of synchronous serous ovarian cancer and uterine serous endometrial intraepithelial carcinoma
por: Shimizu, Maho, et al.
Publicado: (2021)

p16INK4a in cellular senescence
por: Simboeck, Elisabeth, et al.
Publicado: (2013)

p16(INK4a) Expression in Porokeratosis
por: Uryu, Miki, et al.
Publicado: (2017)

HER2 Oncogene as Molecular Target in Uterine Serous Carcinoma and Uterine Carcinosarcoma
por: McNamara, Blair, et al.
Publicado: (2023)

RTA Promoter Demethylation and Histone Acetylation Regulation of Murine Gammaherpesvirus 68 Reactivation
por: Yang, Zhangsheng, et al.
Publicado: (2009)

Analysis of Jmjd6 Cellular Localization and Testing for Its Involvement in Histone Demethylation
por: Hahn, Phillip, et al.
Publicado: (2010)

Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases
por: Walport, Louise J., et al.
Publicado: (2016)

SET oncoprotein accumulation regulates transcription through DNA demethylation and histone hypoacetylation
por: Almeida, Luciana O., et al.
Publicado: (2017)

Control of Foxp3 induction and maintenance by sequential histone acetylation and DNA demethylation
por: Li, Jun, et al.
Publicado: (2021)

The effects of transferring tumor suppressor gene p16(INK4A) to p16(INK4A)-deleted cancer cells*
por: Lee, Kye Young, et al.
Publicado: (1999)

Transcriptional Regulation of 15-Lipoxygenase Expression by Histone H3 Lysine 4 Methylation/Demethylation
por: Liu, Cheng, et al.
Publicado: (2012)

P16(INK4A) is required for cisplatin resistance in cervical carcinoma SiHa cells
por: LI, YUERAN, et al.
Publicado: (2015)

Biological Aging Marker p16(INK4a) in T Cells and Breast Cancer Risk
por: Shen, Jie, et al.
Publicado: (2020)

Somatic p16(INK4a) loss accelerates melanomagenesis
por: Monahan, K B, et al.
Publicado: (2010)

Prevalence and Prognostic Relevance of Homologous Recombination Repair Gene Mutations in Uterine Serous Carcinoma
por: Dong, Lin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_k0mauj0n8qkfbg9clssfag5ran