Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in cis

The group A p21-activated kinases (PAKs) exist in an auto-inhibited form until activated by GTPase binding and auto-phosphorylation. In the auto-inhibited form, a regulatory domain binds to the kinase domain (KD) blocking the binding of substrates, and CDC42 or Rac binding to the regulatory domain r...

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Detalles Bibliográficos
Autores principales: Sorrell, Fiona J., Kilian, Lena Marie, Elkins, Jonathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448136/
https://www.ncbi.nlm.nih.gov/pubmed/30858169
http://dx.doi.org/10.1042/BCJ20180867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448136/
https://www.ncbi.nlm.nih.gov/pubmed/30858169
http://dx.doi.org/10.1042/BCJ20180867

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