Activation of the hypoxia pathway in breast cancer tissue and patient survival are inversely associated with tumor ascorbate levels

BACKGROUND: The transcription factor hypoxia inducible factor (HIF) -1 drives tumor growth and metastasis and is associated with poor prognosis in breast cancer. Ascorbate can moderate HIF-1 activity in vitro and is associated with HIF pathway activation in a number of cancer types, but whether tiss...

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Detalles Bibliográficos
Autores principales: Campbell, Elizabeth J., Dachs, Gabi U., Morrin, Helen R., Davey, Valerie C., Robinson, Bridget A., Vissers, Margreet C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448303/
https://www.ncbi.nlm.nih.gov/pubmed/30943919
http://dx.doi.org/10.1186/s12885-019-5503-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448303/
https://www.ncbi.nlm.nih.gov/pubmed/30943919
http://dx.doi.org/10.1186/s12885-019-5503-x

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