Cargando…

Activation of the hypoxia pathway in breast cancer tissue and patient survival are inversely associated with tumor ascorbate levels

BACKGROUND: The transcription factor hypoxia inducible factor (HIF) -1 drives tumor growth and metastasis and is associated with poor prognosis in breast cancer. Ascorbate can moderate HIF-1 activity in vitro and is associated with HIF pathway activation in a number of cancer types, but whether tiss...

Descripción completa

Detalles Bibliográficos
Autores principales:	Campbell, Elizabeth J., Dachs, Gabi U., Morrin, Helen R., Davey, Valerie C., Robinson, Bridget A., Vissers, Margreet C. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448303/ https://www.ncbi.nlm.nih.gov/pubmed/30943919 http://dx.doi.org/10.1186/s12885-019-5503-x

Ejemplares similares

The Association Between Ascorbate and the Hypoxia-Inducible Factors in Human Renal Cell Carcinoma Requires a Functional Von Hippel-Lindau Protein
por: Wohlrab, Christina, et al.
Publicado: (2018)

Increased Tumor Ascorbate is Associated with Extended Disease-Free Survival and Decreased Hypoxia-Inducible Factor-1 Activation in Human Colorectal Cancer
por: Kuiper, Caroline, et al.
Publicado: (2014)

Restoring physiological levels of ascorbate slows tumor growth and moderates HIF-1 pathway activity in Gulo(−/−) mice
por: Campbell, Elizabeth J, et al.
Publicado: (2015)

Gulonolactone Addition to Human Hepatocellular Carcinoma Cells with Gene Transfer of Gulonolactone Oxidase Restores Ascorbate Biosynthesis and Reduces Hypoxia Inducible Factor 1
por: Flett, Teresa, et al.
Publicado: (2014)

Ascorbate availability affects tumor implantation-take rate and increases tumor rejection in Gulo(−/−) mice
por: Campbell, Elizabeth J, et al.
Publicado: (2016)

Increased Ascorbate Content of Glioblastoma Is Associated With a Suppressed Hypoxic Response and Improved Patient Survival
por: Burgess, Eleanor R., et al.
Publicado: (2022)

Ascorbate modulates the hypoxic pathway by increasing intracellular activity of the HIF hydroxylases in renal cell carcinoma cells
por: Wohlrab, Christina, et al.
Publicado: (2019)

Vitamin C Administration by Intravenous Infusion Increases Tumor Ascorbate Content in Patients With Colon Cancer: A Clinical Intervention Study
por: Dachs, Gabi U., et al.
Publicado: (2021)

Ascorbate content of clinical glioma tissues is related to tumour grade and to global levels of 5-hydroxymethyl cytosine
por: Crake, Rebekah L. I., et al.
Publicado: (2022)

Erythrocyte Ascorbate Is a Potential Indicator of Steady-State Plasma Ascorbate Concentrations in Healthy Non-Fasting Individuals
por: M. Pullar, Juliet, et al.
Publicado: (2020)

Ascorbate Uptake and Retention by Breast Cancer Cell Lines and the Intracellular Distribution of Sodium-Dependent Vitamin C Transporter 2
por: Praditi, Citra, et al.
Publicado: (2023)

Current Limitations of Murine Models in Oncology for Ascorbate Research
por: Campbell, Elizabeth J., et al.
Publicado: (2014)

Gene and Protein Expression Is Altered by Ascorbate Availability in Murine Macrophages Cultured under Tumour-Like Conditions
por: Ang, Abel D., et al.
Publicado: (2021)

Low Vitamin C Status in Patients with Cancer Is Associated with Patient and Tumor Characteristics
por: White, Rebecca, et al.
Publicado: (2020)

A profile of prognostic and molecular factors in European and Māori breast cancer patients
por: Dachs, Gabi U, et al.
Publicado: (2010)

Effect of post-implant exercise on tumour growth rate, perfusion and hypoxia in mice
por: Buss, Linda A., et al.
Publicado: (2020)

Ascorbate as a Co-Factor for Fe- and 2-Oxoglutarate Dependent Dioxygenases: Physiological Activity in Tumor Growth and Progression
por: Kuiper, Caroline, et al.
Publicado: (2014)

Emerging epigenetic therapeutics for myeloid leukemia: modulating demethylase activity with ascorbate
por: Das, Andrew B., et al.
Publicado: (2020)

The Role of 2-Oxoglutarate Dependent Dioxygenases in Gliomas and Glioblastomas: A Review of Epigenetic Reprogramming and Hypoxic Response
por: Crake, Rebekah L. I., et al.
Publicado: (2021)

Marginal Ascorbate Status (Hypovitaminosis C) Results in an Attenuated Response to Vitamin C Supplementation
por: Carr, Anitra C., et al.
Publicado: (2016)

Anti-vascular agent Combretastatin A-4-P modulates Hypoxia Inducible Factor-1 and gene expression
por: Dachs, Gabi U, et al.
Publicado: (2006)

Marginal effects of glucose, insulin and insulin-like growth factor on chemotherapy response in endothelial and colorectal cancer cells
por: VOLKOVA, EKATERINA, et al.
Publicado: (2014)

Ascorbate Inhibits Proliferation and Promotes Myeloid Differentiation in TP53-Mutant Leukemia
por: Smith-Díaz, Carlos C., et al.
Publicado: (2021)

Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations(1)(2)(3)
por: Carr, Anitra C, et al.
Publicado: (2013)

Clinical remission following ascorbate treatment in a case of acute myeloid leukemia with mutations in TET2 and WT1
por: Das, Andrew B., et al.
Publicado: (2019)

Patients’ and carers’ priorities for cancer research in Aotearoa/New Zealand
por: de Vries, Millie, et al.
Publicado: (2023)

Positive Association of Ascorbate and Inverse Association of Urate with Cognitive Function in People with Parkinson’s Disease
por: Spencer, Emma S., et al.
Publicado: (2020)

Effect of immune modulation on the skeletal muscle mitochondrial exercise response: An exploratory study in mice with cancer
por: Buss, Linda A., et al.
Publicado: (2021)

Vitamin C Transporters in Cancer: Current Understanding and Gaps in Knowledge
por: Wohlrab, Christina, et al.
Publicado: (2017)

Contrasting effects of ascorbate and iron on the pulmonary vascular response to hypoxia in humans
por: Talbot, Nick P., et al.
Publicado: (2014)

Ascorbic acid does not enhance hypoxia‐induced vasodilation in healthy older men
por: Pollock, Jonathan P., et al.
Publicado: (2014)

Membrane Permeabilities of Ascorbic Acid and Ascorbate
por: Hannesschlaeger, Christof, et al.
Publicado: (2018)

Bystander or No Bystander for Gene Directed Enzyme Prodrug Therapy
por: Dachs, Gabi U., et al.
Publicado: (2009)

Synthetic or Food-Derived Vitamin C—Are They Equally Bioavailable?
por: Carr, Anitra C., et al.
Publicado: (2013)

Synovial tissue hypoxia and inflammation in vivo
por: Ng, C T, et al.
Publicado: (2010)

Direct visualization of electroporation-assisted in vivo gene delivery to tumors using intravital microscopy – spatial and time dependent distribution
por: Cemazar, Maja, et al.
Publicado: (2004)

Potential Mechanisms of Action for Vitamin C in Cancer: Reviewing the Evidence
por: Vissers, Margreet C. M., et al.
Publicado: (2018)

Biomolecular and cellular effects in skin wound healing: the association between ascorbic acid and hypoxia-induced factor
por: Ghahremani-Nasab, Maryam, et al.
Publicado: (2023)

Synovial hypoxia inducible factor-1α expression is inversely related to tissue oxygen levels in vivo in inflammatory arthritis
por: Donatien, P, et al.
Publicado: (2005)

The Effect of Intravenous Vitamin C on Cancer- and Chemotherapy-Related Fatigue and Quality of Life
por: Carr, Anitra C., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_uqbde7uj355vr32dtat9c3meh8