An Engineered Human Fc variant With Exquisite Selectivity for FcγRIIIa(V158) Reveals That Ligation of FcγRIIIa Mediates Potent Antibody Dependent Cellular Phagocytosis With GM-CSF-Differentiated Macrophages

IgG antibodies mediate the clearance of target cells via the engagement of Fc gamma receptors (FcγRs) on effector cells by eliciting antibody-dependent cellular cytotoxicity and phagocytosis (ADCC and ADCP, respectively). Because (i) the IgG Fc domain binds to multiple FcγRs with varying affinities;...

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Detalles Bibliográficos
Autores principales: Kang, Tae Hyun, Lee, Chang-Han, Delidakis, George, Jung, Jiwon, Richard-Le Goff, Odile, Lee, Jiwon, Kim, Jin Eyun, Charab, Wissam, Bruhns, Pierre, Georgiou, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448688/
https://www.ncbi.nlm.nih.gov/pubmed/30984171
http://dx.doi.org/10.3389/fimmu.2019.00562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448688/
https://www.ncbi.nlm.nih.gov/pubmed/30984171
http://dx.doi.org/10.3389/fimmu.2019.00562

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