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GTS-21 has cell-specific anti-inflammatory effects independent of α7 nicotinic acetylcholine receptors
α7 Nicotinic acetylcholine receptors (nAChRs) reportedly reduce inflammation by blocking effects of the important pro-inflammatory transcription factor, nuclear factor kappa-light chain-enhancer of B cells (NFκB). The α7 nAChR partial agonist GTS-21 reduces secretion of pro-inflammatory cytokines in...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448884/ https://www.ncbi.nlm.nih.gov/pubmed/30947238 http://dx.doi.org/10.1371/journal.pone.0214942 |