Cargando…

GTS-21 has cell-specific anti-inflammatory effects independent of α7 nicotinic acetylcholine receptors

α7 Nicotinic acetylcholine receptors (nAChRs) reportedly reduce inflammation by blocking effects of the important pro-inflammatory transcription factor, nuclear factor kappa-light chain-enhancer of B cells (NFκB). The α7 nAChR partial agonist GTS-21 reduces secretion of pro-inflammatory cytokines in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Garg, Brijesh K., Loring, Ralph H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448884/ https://www.ncbi.nlm.nih.gov/pubmed/30947238 http://dx.doi.org/10.1371/journal.pone.0214942

Ejemplares similares

Anti-Inflammatory and Neuroprotective Mechanisms of GTS-21, an α7 Nicotinic Acetylcholine Receptor Agonist, in Neuroinflammation and Parkinson’s Disease Mouse Models
por: Park, Jung-Eun, et al.
Publicado: (2022)

The selective α7 nicotinic acetylcholine receptor agonist GTS-21 attenuates ventilator-induced inflammation and lung injury
por: Kox, M, et al.
Publicado: (2009)

Effects of splenectomy and GTS-21, a selective α7 nicotinic acetylcholine receptor agonist, on the development of septic ileus in mice
por: Nullens, S, et al.
Publicado: (2014)

α7 nicotinic acetylcholine receptor agonist GTS-21 attenuates DSS-induced intestinal colitis by improving intestinal mucosal barrier function
por: Ye, Ziping, et al.
Publicado: (2022)

The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation
por: Sitapara, Ravikumar A., et al.
Publicado: (2020)

GTS-21, an α7-nicotinic acetylcholine receptor agonist, modulates Th1 differentiation in CD4(+) T cells from patients with rheumatoid arthritis
por: WU, SHIYAO, et al.
Publicado: (2014)

Expression of Concern to: The α7 nicotine acetylcholine receptor agonist GTS-21 improves bacterial clearance in mice by restoring hyperoxia-compromised macrophage function
por: Sitapara, Ravikumar A., et al.
Publicado: (2020)

Retraction Note: The α7 nicotinic acetylcholine receptor agonist GTS-21 improves bacterial clearance in mice by restoring hyperoxia-compromised macrophage function
por: Sitapara, Ravikumar A., et al.
Publicado: (2020)

The α7 Nicotinic Acetylcholine Receptor Agonist GTS-21 Improves Bacterial Clearance via Regulation of Monocyte Recruitment and Activity in Polymicrobial Septic Peritonitis
por: Hu, Jian-nan, et al.
Publicado: (2022)

GTS-21, a selective alpha7 nicotinic acetylcholine receptor agonist, ameliorates diabetic nephropathy in Lepr(db/db) mice
por: Meng, Qinghe, et al.
Publicado: (2022)

Anti-inflammatory effects of astroglial α7 nicotinic acetylcholine receptors are mediated by inhibition of the NF-κB pathway and activation of the Nrf2 pathway
por: Patel, Hiral, et al.
Publicado: (2017)

Attenuation of Collagen-Induced Arthritis in Rat by Nicotinic Alpha7 Receptor Partial Agonist GTS-21
por: Hu, Yiping, et al.
Publicado: (2014)

Anti-inflammatory effects of Kupffer cells through α7-nicotinic acetylcholine receptors
por: Li, Y, et al.
Publicado: (2013)

Acetylcholine receptors in the retinas of the α7 nicotinic acetylcholine receptor knockout mouse
por: Smith, Marci L., et al.
Publicado: (2014)

α7 nicotinic acetylcholine receptor upregulation by anti-apoptotic Bcl-2 proteins
por: Dawe, G. Brent, et al.
Publicado: (2019)

Menthol Binding and Inhibition of α7-Nicotinic Acetylcholine Receptors
por: Ashoor, Abrar, et al.
Publicado: (2013)

Mechanism of calcium potentiation of the α7 nicotinic acetylcholine receptor
por: Natarajan, Kathiresan, et al.
Publicado: (2020)

Role of the α7 Nicotinic Acetylcholine Receptor in the Pathophysiology of Atherosclerosis
por: Vieira-Alves, Ildernandes, et al.
Publicado: (2020)

Targeting α7 nicotinic acetylcholine receptors for chronic pain
por: Zhou, Ya-Qun, et al.
Publicado: (2022)

Acute Lung Injury in Cholinergic-Deficient Mice Supports Anti-Inflammatory Role of α7 Nicotinic Acetylcholine Receptor
por: Pinheiro, Nathalia M., et al.
Publicado: (2021)

α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect
por: Liu, Huiyang, et al.
Publicado: (2023)

Speculation on How RIC-3 and Other Chaperones Facilitate α7 Nicotinic Receptor Folding and Assembly
por: Loring, Ralph H.
Publicado: (2022)

Activation of the cholinergic anti-inflammatory pathway by GTS-21 attenuates cisplatin-induced acute kidney injury in mice
por: Chatterjee, Prodyot K., et al.
Publicado: (2017)

Expression of the α7 nicotinic acetylcholine receptor in human lung cells
por: Plummer, Howard K, et al.
Publicado: (2005)

Modulation of dopamine release by α7-type nicotinic acetylcholine receptors
por: Maex, Reinoud, et al.
Publicado: (2013)

Methylpiperidinium Iodides as Novel Antagonists for α7 Nicotinic Acetylcholine Receptors
por: López, Jhon J., et al.
Publicado: (2018)

Cloning and Expression of Cockroach α7 Nicotinic Acetylcholine Receptor Subunit
por: Cartereau, Alison, et al.
Publicado: (2020)

Structural basis of human α7 nicotinic acetylcholine receptor activation
por: Zhao, Yue, et al.
Publicado: (2021)

Activation of α7 nicotinic acetylcholine receptor retards the development of endometriosis
por: Hao, Meihua, et al.
Publicado: (2022)

GTS-21 Promotes α7 nAChR to Alleviate Intestinal Ischemia-Reperfusion-Induced Apoptosis and Inflammation of Enterocytes
por: Wang, Haisong, et al.
Publicado: (2020)

Nicotine stimulates collagen type I expression in lung via α7 nicotinic acetylcholine receptors
por: Vicary, Glenn W., et al.
Publicado: (2017)

Autophagy Plays an Important Role in Anti-inflammatory Mechanisms Stimulated by Alpha7 Nicotinic Acetylcholine Receptor
por: Shao, Bo-Zong, et al.
Publicado: (2017)

An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein
por: Delbart, Florian, et al.
Publicado: (2018)

Sazetidine-A Activates and Desensitizes Native α7 Nicotinic Acetylcholine Receptors
por: Brown, Jack L., et al.
Publicado: (2014)

How calcium helps α7 nicotinic acetylcholine receptors fulfill their potential
por: Short, Ben
Publicado: (2020)

Nicotinic Acetylcholine Receptor α7 Subunit Is an Essential Regulator of Seizure Susceptibility
por: Sun, Peng, et al.
Publicado: (2021)

Activation of α7 nicotinic acetylcholine receptor promotes HIV-1 transcription
por: Wen, Jing, et al.
Publicado: (2022)

GTS-21, an α7nAChR agonist, suppressed the production of key inflammatory mediators by PBMCs that are elevated in COPD patients and associated with impaired lung function
por: Douaoui, Sana, et al.
Publicado: (2020)

Effect of the a7nAChR agonist GTS-21 on inflammation during human endotoxemia
por: Pompe, J, et al.
Publicado: (2009)

α7- and α9-Containing Nicotinic Acetylcholine Receptors in the Functioning of Immune System and in Pain
por: Shelukhina, Irina, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_272sadesjl442sfmdjotce2tv6