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HSP-4/BiP expression in secretory cells is regulated by a developmental program and not by the unfolded protein response
Differentiation of secretory cells leads to sharp increases in protein synthesis, challenging endoplasmic reticulum (ER) proteostasis. Anticipatory activation of the unfolded protein response (UPR) prepares cells for the onset of secretory function by expanding the ER size and folding capacity. How...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448932/ https://www.ncbi.nlm.nih.gov/pubmed/30908491 http://dx.doi.org/10.1371/journal.pbio.3000196 |