Skeletal muscle insulin resistance is induced by 4-hydroxy-2-hexenal, a by-product of n-3 fatty acid peroxidation

AIMS/HYPOTHESIS: Oxidative stress is involved in the pathophysiology of insulin resistance and its progression towards type 2 diabetes. The peroxidation of n-3 polyunsaturated fatty acids produces 4-hydroxy-2-hexenal (4-HHE), a lipid aldehyde with potent electrophilic properties able to interfere wi...

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Detalles Bibliográficos
Autores principales: Soulage, Christophe O., Sardón Puig, Laura, Soulère, Laurent, Zarrouki, Bader, Guichardant, Michel, Lagarde, Michel, Pillon, Nicolas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448972/
https://www.ncbi.nlm.nih.gov/pubmed/29299636
http://dx.doi.org/10.1007/s00125-017-4528-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448972/
https://www.ncbi.nlm.nih.gov/pubmed/29299636
http://dx.doi.org/10.1007/s00125-017-4528-4

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