B cell depletion reduces T cell activation in pancreatic islets in a murine autoimmune diabetes model

AIMS/HYPOTHESIS: Type 1 diabetes is a T cell-mediated autoimmune disease characterised by the destruction of beta cells in the islets of Langerhans, resulting in deficient insulin production. B cell depletion therapy has proved successful in preventing diabetes and restoring euglycaemia in animal mo...

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Detalles Bibliográficos
Autores principales: Da Rosa, Larissa C., Boldison, Joanne, De Leenheer, Evy, Davies, Joanne, Wen, Li, Wong, F. Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449006/
https://www.ncbi.nlm.nih.gov/pubmed/29594371
http://dx.doi.org/10.1007/s00125-018-4597-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449006/
https://www.ncbi.nlm.nih.gov/pubmed/29594371
http://dx.doi.org/10.1007/s00125-018-4597-z

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