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Identification of Lysine Misincorporation at Asparagine Position in Recombinant Insulin Analogs Produced in E. coli
PURPOSE: Identification of human insulin analogs’ impurity with a mass shift +14 Da in comparison to a parent protein. METHODS: The protein sequence variant was detected and identified with the application of peptide mapping, liquid chromatography, tandem mass spectrometric analysis, nuclear magneti...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449291/ https://www.ncbi.nlm.nih.gov/pubmed/30949841 http://dx.doi.org/10.1007/s11095-019-2601-z |