Identification of Lysine Misincorporation at Asparagine Position in Recombinant Insulin Analogs Produced in E. coli

PURPOSE: Identification of human insulin analogs’ impurity with a mass shift +14 Da in comparison to a parent protein. METHODS: The protein sequence variant was detected and identified with the application of peptide mapping, liquid chromatography, tandem mass spectrometric analysis, nuclear magneti...

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Detalles Bibliográficos
Autores principales: Stadnik, Dorota, Bierczyńska-Krzysik, Anna, Zielińska, Joanna, Antosik, Jarosław, Borowicz, Piotr, Bednarek, Elżbieta, Bocian, Wojciech, Sitkowski, Jerzy, Kozerski, Lech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449291/
https://www.ncbi.nlm.nih.gov/pubmed/30949841
http://dx.doi.org/10.1007/s11095-019-2601-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449291/
https://www.ncbi.nlm.nih.gov/pubmed/30949841
http://dx.doi.org/10.1007/s11095-019-2601-z

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