Structural basis of translation inhibition by cadazolid, a novel quinoxolidinone antibiotic

Oxazolidinones are synthetic antibiotics used for treatment of infections caused by Gram-positive bacteria. They target the bacterial protein synthesis machinery by binding to the peptidyl transferase centre (PTC) of the ribosome and interfering with the peptidyl transferase reaction. Cadazolid is t...

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Detalles Bibliográficos
Autores principales: Scaiola, Alain, Leibundgut, Marc, Boehringer, Daniel, Caspers, Patrick, Bur, Daniel, Locher, Hans H., Rueedi, Georg, Ritz, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449356/
https://www.ncbi.nlm.nih.gov/pubmed/30948752
http://dx.doi.org/10.1038/s41598-019-42155-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449356/
https://www.ncbi.nlm.nih.gov/pubmed/30948752
http://dx.doi.org/10.1038/s41598-019-42155-4

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