A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma

Transition between differentiation states in development occurs swift but the mechanisms leading to epigenetic and transcriptional reprogramming are poorly understood. The pediatric cancer neuroblastoma includes adrenergic (ADRN) and mesenchymal (MES) tumor cell types, which differ in phenotype, sup...

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Detalles Bibliográficos
Autores principales: van Groningen, Tim, Akogul, Nurdan, Westerhout, Ellen M., Chan, Alvin, Hasselt, Nancy E., Zwijnenburg, Danny A., Broekmans, Marloes, Stroeken, Peter, Haneveld, Franciska, Hooijer, Gerrit K. J., Savci-Heijink, C. Dilara, Lakeman, Arjan, Volckmann, Richard, van Sluis, Peter, Valentijn, Linda J., Koster, Jan, Versteeg, Rogier, van Nes, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449373/
https://www.ncbi.nlm.nih.gov/pubmed/30948783
http://dx.doi.org/10.1038/s41467-019-09470-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449373/
https://www.ncbi.nlm.nih.gov/pubmed/30948783
http://dx.doi.org/10.1038/s41467-019-09470-w

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