Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue

The insulin/IGF-1 signalling pathway is a key regulator of metabolism and the rate of ageing. We previously documented that systemic inactivation of phosphoinositide 3-kinase (PI3K) p110α, the principal PI3K isoform that positively regulates insulin signalling, results in a beneficial metabolic effe...

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Detalles Bibliográficos
Autores principales: Araiz, Caroline, Yan, Anqi, Bettedi, Lucia, Samuelson, Isabella, Virtue, Sam, McGavigan, Anne K., Dani, Christian, Vidal-Puig, Antonio, Foukas, Lazaros C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449391/
https://www.ncbi.nlm.nih.gov/pubmed/30948720
http://dx.doi.org/10.1038/s41467-019-09514-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449391/
https://www.ncbi.nlm.nih.gov/pubmed/30948720
http://dx.doi.org/10.1038/s41467-019-09514-1

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