Mad1 destabilizes p53 by preventing PML from sequestering MDM2

Mitotic arrest deficient 1 (Mad1) plays a well-characterized role in the mitotic checkpoint. However, interphase roles of Mad1 that do not impact mitotic checkpoint function remain largely uncharacterized. Here we show that upregulation of Mad1, which is common in human breast cancer, prevents stres...

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Detalles Bibliográficos
Autores principales: Wan, Jun, Block, Samuel, Scribano, Christina M., Thiry, Rebecca, Esbona, Karla, Audhya, Anjon, Weaver, Beth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449396/
https://www.ncbi.nlm.nih.gov/pubmed/30948704
http://dx.doi.org/10.1038/s41467-019-09471-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449396/
https://www.ncbi.nlm.nih.gov/pubmed/30948704
http://dx.doi.org/10.1038/s41467-019-09471-9

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