Metabolic stress controls mutant p53 R248Q stability in acute myeloid leukemia cells

Eliminating mutant p53 (mt p53) protein could be a useful strategy to treat mt p53 tumors and potentially improve the prognosis of cancer patients. In this study, we unveil different mechanisms that eliminate p53-R248Q, one of the most frequent mutants found in human cancers. We show that the Hsp90...

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Detalles Bibliográficos
Autores principales: Allende-Vega, Nerea, Villalba, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449403/
https://www.ncbi.nlm.nih.gov/pubmed/30948782
http://dx.doi.org/10.1038/s41598-019-42220-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449403/
https://www.ncbi.nlm.nih.gov/pubmed/30948782
http://dx.doi.org/10.1038/s41598-019-42220-y

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