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Metabolic stress controls mutant p53 R248Q stability in acute myeloid leukemia cells
Eliminating mutant p53 (mt p53) protein could be a useful strategy to treat mt p53 tumors and potentially improve the prognosis of cancer patients. In this study, we unveil different mechanisms that eliminate p53-R248Q, one of the most frequent mutants found in human cancers. We show that the Hsp90...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449403/ https://www.ncbi.nlm.nih.gov/pubmed/30948782 http://dx.doi.org/10.1038/s41598-019-42220-y |