High-Dose Paraquat Induces Human Bronchial 16HBE Cell Death and Aggravates Acute Lung Intoxication in Mice by Regulating Keap1/p65/Nrf2 Signal Pathway

Paraquat (PQ) intoxication seriously endangers human beings’ health, however, the underlying mechanisms are still unclear. Here we found that PQ inhibits human bronchial 16HBE cell proliferation and promotes cell apoptosis, necrosis as well as ROS generation in a dose dependent manner. Of note, low-...

Descripción completa

Detalles Bibliográficos
Autores principales: Yao, Jiexiong, Zhang, Jihua, Tai, Wenlin, Deng, Shuhao, Li, Ting, Wu, Wenjuan, Pu, Lin, Fan, Du, Lei, Wen, Zhang, Tao, Dong, Zhaoxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449493/
https://www.ncbi.nlm.nih.gov/pubmed/30734183
http://dx.doi.org/10.1007/s10753-018-00956-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449493/
https://www.ncbi.nlm.nih.gov/pubmed/30734183
http://dx.doi.org/10.1007/s10753-018-00956-1

Ejemplares similares