MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance

CDK4/6 inhibition is now part of the standard armamentarium for patients with estrogen receptorpositive (ER(+)) breast cancer, so that defining mechanisms of resistance is a pressing issue. Here, we identify increased CDK6 expression as a key determinant of acquired resistance after palbociclib trea...

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Detalles Bibliográficos
Autores principales: Cornell, Liam, Wander, Seth A., Visal, Tanvi, Wagle, Nikhil, Shapiro, Geoffrey I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449498/
https://www.ncbi.nlm.nih.gov/pubmed/30840889
http://dx.doi.org/10.1016/j.celrep.2019.02.023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449498/
https://www.ncbi.nlm.nih.gov/pubmed/30840889
http://dx.doi.org/10.1016/j.celrep.2019.02.023

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