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MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance
CDK4/6 inhibition is now part of the standard armamentarium for patients with estrogen receptorpositive (ER(+)) breast cancer, so that defining mechanisms of resistance is a pressing issue. Here, we identify increased CDK6 expression as a key determinant of acquired resistance after palbociclib trea...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449498/ https://www.ncbi.nlm.nih.gov/pubmed/30840889 http://dx.doi.org/10.1016/j.celrep.2019.02.023 |