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Meta-analysis of genome-wide association studies provides insights into genetic control of tomato flavor
Tomato flavor has changed over the course of long-term domestication and intensive breeding. To understand the genetic control of flavor, we report the meta-analysis of genome-wide association studies (GWAS) using 775 tomato accessions and 2,316,117 SNPs from three GWAS panels. We discover 305 signi...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449550/ https://www.ncbi.nlm.nih.gov/pubmed/30948717 http://dx.doi.org/10.1038/s41467-019-09462-w |
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author | Zhao, Jiantao Sauvage, Christopher Zhao, Jinghua Bitton, Frédérique Bauchet, Guillaume Liu, Dan Huang, Sanwen Tieman, Denise M. Klee, Harry J. Causse, Mathilde |
author_facet | Zhao, Jiantao Sauvage, Christopher Zhao, Jinghua Bitton, Frédérique Bauchet, Guillaume Liu, Dan Huang, Sanwen Tieman, Denise M. Klee, Harry J. Causse, Mathilde |
author_sort | Zhao, Jiantao |
collection | PubMed |
description | Tomato flavor has changed over the course of long-term domestication and intensive breeding. To understand the genetic control of flavor, we report the meta-analysis of genome-wide association studies (GWAS) using 775 tomato accessions and 2,316,117 SNPs from three GWAS panels. We discover 305 significant associations for the contents of sugars, acids, amino acids, and flavor-related volatiles. We demonstrate that fruit citrate and malate contents have been impacted by selection during domestication and improvement, while sugar content has undergone less stringent selection. We suggest that it may be possible to significantly increase volatiles that positively contribute to consumer preferences while reducing unpleasant volatiles, by selection of the relevant allele combinations. Our results provide genetic insights into the influence of human selection on tomato flavor and demonstrate the benefits obtained from meta-analysis. |
format | Online Article Text |
id | pubmed-6449550 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-64495502019-04-08 Meta-analysis of genome-wide association studies provides insights into genetic control of tomato flavor Zhao, Jiantao Sauvage, Christopher Zhao, Jinghua Bitton, Frédérique Bauchet, Guillaume Liu, Dan Huang, Sanwen Tieman, Denise M. Klee, Harry J. Causse, Mathilde Nat Commun Article Tomato flavor has changed over the course of long-term domestication and intensive breeding. To understand the genetic control of flavor, we report the meta-analysis of genome-wide association studies (GWAS) using 775 tomato accessions and 2,316,117 SNPs from three GWAS panels. We discover 305 significant associations for the contents of sugars, acids, amino acids, and flavor-related volatiles. We demonstrate that fruit citrate and malate contents have been impacted by selection during domestication and improvement, while sugar content has undergone less stringent selection. We suggest that it may be possible to significantly increase volatiles that positively contribute to consumer preferences while reducing unpleasant volatiles, by selection of the relevant allele combinations. Our results provide genetic insights into the influence of human selection on tomato flavor and demonstrate the benefits obtained from meta-analysis. Nature Publishing Group UK 2019-04-04 /pmc/articles/PMC6449550/ /pubmed/30948717 http://dx.doi.org/10.1038/s41467-019-09462-w Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Zhao, Jiantao Sauvage, Christopher Zhao, Jinghua Bitton, Frédérique Bauchet, Guillaume Liu, Dan Huang, Sanwen Tieman, Denise M. Klee, Harry J. Causse, Mathilde Meta-analysis of genome-wide association studies provides insights into genetic control of tomato flavor |
title | Meta-analysis of genome-wide association studies provides insights into genetic control of tomato flavor |
title_full | Meta-analysis of genome-wide association studies provides insights into genetic control of tomato flavor |
title_fullStr | Meta-analysis of genome-wide association studies provides insights into genetic control of tomato flavor |
title_full_unstemmed | Meta-analysis of genome-wide association studies provides insights into genetic control of tomato flavor |
title_short | Meta-analysis of genome-wide association studies provides insights into genetic control of tomato flavor |
title_sort | meta-analysis of genome-wide association studies provides insights into genetic control of tomato flavor |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449550/ https://www.ncbi.nlm.nih.gov/pubmed/30948717 http://dx.doi.org/10.1038/s41467-019-09462-w |
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