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Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia

The effects of hyperuricemia on the expression of kidney drug transporters and on the pharmacokinetics of several substrate drugs were examined. We first established a rat model of hyperuricemia without marked symptoms of chronic kidney failure by 10-day co-administration of oxonic acid (uricase inh...

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Detalles Bibliográficos
Autores principales: Nishizawa, Kei, Yoda, Noriaki, Morokado, Fumi, Komori, Hisakazu, Nakanishi, Takeo, Tamai, Ikumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450621/
https://www.ncbi.nlm.nih.gov/pubmed/30951542
http://dx.doi.org/10.1371/journal.pone.0214862