Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions

The mechanism that leads to liquid-liquid phase separation (LLPS) of the tau protein, whose pathological aggregation is implicated in neurodegenerative disorders, is not well understood. Establishing a phase diagram that delineates the boundaries of phase co-existence is key to understanding whether...

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Detalles Bibliográficos
Autores principales: Lin, Yanxian, McCarty, James, Rauch, Jennifer N, Delaney, Kris T, Kosik, Kenneth S, Fredrickson, Glenn H, Shea, Joan-Emma, Han, Songi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450672/
https://www.ncbi.nlm.nih.gov/pubmed/30950394
http://dx.doi.org/10.7554/eLife.42571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450672/
https://www.ncbi.nlm.nih.gov/pubmed/30950394
http://dx.doi.org/10.7554/eLife.42571

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