Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition

Ataxia telangiectasia mutated and RAD3 related (ATR) protein kinase plays critical roles in ensuring DNA replication, DNA repair, and cell cycle control in response to replication stress, making ATR inhibition a promising therapeutic strategy for cancer treatment. To identify genes whose loss makes...

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Detalles Bibliográficos
Autores principales: Wang, Chao, Wang, Gang, Feng, Xu, Shepherd, Peter, Zhang, Jie, Tang, Mengfan, Chen, Zhen, Srivastava, Mrinal, McLaughlin, Megan E., Navone, Nora M., Hart, Glen Traver, Chen, Junjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450769/
https://www.ncbi.nlm.nih.gov/pubmed/30532030
http://dx.doi.org/10.1038/s41388-018-0606-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450769/
https://www.ncbi.nlm.nih.gov/pubmed/30532030
http://dx.doi.org/10.1038/s41388-018-0606-4

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