Cargando…

Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers

Alzheimer’s disease (AD) is a neurodegenerative disorder leading to dementia. Aggregation of the amyloid-β peptide (Aβ) plays an important role in the disease, with Aβ oligomers representing the most toxic species. Previously, we have developed the Aβ oligomer eliminating therapeutic compound RD2 co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Elfgen, Anne, Hupert, Michelle, Bochinsky, Kevin, Tusche, Markus, González de San Román Martin, Estibaliz, Gering, Ian, Sacchi, Silvia, Pollegioni, Loredano, Huesgen, Pitter F., Hartmann, Rudolf, Santiago-Schübel, Beatrix, Kutzsche, Janine, Willbold, Dieter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450887/ https://www.ncbi.nlm.nih.gov/pubmed/30952881 http://dx.doi.org/10.1038/s41598-019-41993-6

Ejemplares similares

The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology
por: van Groen, Thomas, et al.
Publicado: (2017)

Optimization of the All-D Peptide D3 for Aβ Oligomer Elimination
por: Klein, Antonia Nicole, et al.
Publicado: (2016)

In Vitro Potency and Preclinical Pharmacokinetic Comparison of All-D-Enantiomeric Peptides Developed for the Treatment of Alzheimer’s Disease
por: Schartmann, Elena, et al.
Publicado: (2018)

Oral Treatment with RD2RD2 Impedes Development of Motoric Phenotype and Delays Symptom Onset in SOD1(G93A) Transgenic Mice
por: Post, Julia, et al.
Publicado: (2021)

QIAD assay for quantitating a compound’s efficacy in elimination of toxic Aβ oligomers
por: Brener, Oleksandr, et al.
Publicado: (2015)

Aβ Oligomer Elimination Restores Cognition in Transgenic Alzheimer’s Mice with Full-blown Pathology
por: Schemmert, Sarah, et al.
Publicado: (2018)

Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity
por: Rudolph, Stephan, et al.
Publicado: (2016)

Correction: Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity
por: Rudolph, Stephan, et al.
Publicado: (2016)

Stabilization of Monomeric Tau Protein by All D-Enantiomeric Peptide Ligands as Therapeutic Strategy for Alzheimer’s Disease and Other Tauopathies
por: Altendorf, Tim, et al.
Publicado: (2023)

Oral Treatment with d-RD2RD2 Impedes Early Disease Mechanisms in SOD1*G93A Transgenic Mice but Does Not Prolong Survival
por: Wintz, Katharina, et al.
Publicado: (2023)

In Vitro and In Vivo Efficacies of the Linear and the Cyclic Version of an All-d-Enantiomeric Peptide Developed for the Treatment of Alzheimer’s Disease
por: Schemmert, Sarah, et al.
Publicado: (2021)

Aβ oligomer concentration in mouse and human brain and its drug-induced reduction ex vivo
por: Kass, Bettina, et al.
Publicado: (2022)

Do We Need Anti-Prionic Compounds to Treat Alzheimer’s Disease?
por: Willbold, Dieter, et al.
Publicado: (2019)

Large-Scale Oral Treatment Study with the Four Most Promising D3-Derivatives for the Treatment of Alzheimer’s Disease
por: Kutzsche, Janine, et al.
Publicado: (2017)

Human D-Amino Acid Oxidase: Structure, Function, and Regulation
por: Pollegioni, Loredano, et al.
Publicado: (2018)

Substitution of Arginine 120 in Human D-Amino Acid Oxidase Favors FAD-Binding and Nuclear Mistargeting
por: Murtas, Giulia, et al.
Publicado: (2019)

Structural details of amyloid β oligomers in complex with human prion protein as revealed by solid-state MAS NMR spectroscopy
por: König, Anna S., et al.
Publicado: (2021)

Biochemical Properties of Human D-Amino Acid Oxidase
por: Murtas, Giulia, et al.
Publicado: (2017)

Human D-aspartate Oxidase: A Key Player in D-aspartate Metabolism
por: Pollegioni, Loredano, et al.
Publicado: (2021)

Yin and Yang in Post-Translational Modifications of Human D-Amino Acid Oxidase
por: Sacchi, Silvia, et al.
Publicado: (2021)

Biochemical Properties and Physiological Functions of pLG72: Twenty Years of Investigations
por: Murtas, Giulia, et al.
Publicado: (2022)

Solution structure of the autophagy-related protein LC3C reveals a polyproline II motif on a mobile tether with phosphorylation site
por: Krichel, Carsten, et al.
Publicado: (2019)

Editorial: Bioscience of D-amino Acid Oxidase From Biochemistry to Pathophysiology
por: Pollegioni, Loredano, et al.
Publicado: (2018)

The conundrum in enzymatic reactions related to biosynthesis of d‐amino acids in bacteria
por: Pollegioni, Loredano, et al.
Publicado: (2022)

D-Amino Acids and Cancer: Friends or Foes?
por: Murtas, Giulia, et al.
Publicado: (2023)

Proline oxidase controls proline, glutamate, and glutamine cellular concentrations in a U87 glioblastoma cell line
por: Cappelletti, Pamela, et al.
Publicado: (2018)

Classical/Non‐classical Polyoxometalate Hybrids
por: Izarova, Natalya V., et al.
Publicado: (2016)

Application of an Amyloid Beta Oligomer Standard in the sFIDA Assay
por: Kühbach, Katja, et al.
Publicado: (2016)

Optimizing HIV-1 protease production in Escherichia coli as fusion protein
por: Volontè, Federica, et al.
Publicado: (2011)

One single method to produce native and Tat-fused recombinant human α-synuclein in Escherichia coli
por: Caldinelli, Laura, et al.
Publicado: (2013)

Advances in Enzymatic Synthesis of D-Amino Acids
por: Pollegioni, Loredano, et al.
Publicado: (2020)

Analytical methods for the investigation of enzyme‐catalyzed degradation of polyethylene terephthalate
por: Pirillo, Valentina, et al.
Publicado: (2021)

Correction to “Whole-Cell Bioconversion of Renewable Biomasses-Related Aromatics to cis,cis-Muconic Acid”
por: Molinari, Filippo, et al.
Publicado: (2023)

Identity of Endogenous NMDAR Glycine Site Agonist in Amygdala Is Determined by Synaptic Activity Level
por: Li, Yan, et al.
Publicado: (2013)

Design of D-Amino Acids SARS-CoV-2 Main Protease Inhibitors Using the Cationic Peptide from Rattlesnake Venom as a Scaffold
por: Eberle, Raphael J., et al.
Publicado: (2022)

Oral treatment with the all-d-peptide RD2 enhances cognition in aged beagle dogs – A model of sporadic Alzheimer’s disease
por: Kutzsche, Janine, et al.
Publicado: (2023)

Serum d-serine levels are altered in early phases of Alzheimer’s disease: towards a precocious biomarker
por: Piubelli, Luciano, et al.
Publicado: (2021)

Serine racemase: a key player in apoptosis and necrosis
por: Canu, Nadia, et al.
Publicado: (2014)

Biosensors for D-Amino Acids: Detection Methods and Applications
por: Rosini, Elena, et al.
Publicado: (2020)

A So-Far Overlooked Secondary Conformation State in the Binding Mode of SARS-CoV-2 Spike Protein to Human ACE2 and Its Conversion Rate Are Crucial for Estimating Infectivity Efficacy of the Underlying Virus Variant
por: Sevenich, Marc, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_jehh02lr07eihpb0gb1nkkae5u