Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects

Only a small fraction of early drug programs progress to the market, due to safety and efficacy failures, despite extensive efforts to predict safety. Characterizing the effect of natural variation in the genes encoding drug targets should present a powerful approach to predict side effects arising...

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Detalles Bibliográficos
Autores principales: Nguyen, Phuong A., Born, David A., Deaton, Aimee M., Nioi, Paul, Ward, Lucas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450952/
https://www.ncbi.nlm.nih.gov/pubmed/30952858
http://dx.doi.org/10.1038/s41467-019-09407-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450952/
https://www.ncbi.nlm.nih.gov/pubmed/30952858
http://dx.doi.org/10.1038/s41467-019-09407-3

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