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Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects
Only a small fraction of early drug programs progress to the market, due to safety and efficacy failures, despite extensive efforts to predict safety. Characterizing the effect of natural variation in the genes encoding drug targets should present a powerful approach to predict side effects arising...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450952/ https://www.ncbi.nlm.nih.gov/pubmed/30952858 http://dx.doi.org/10.1038/s41467-019-09407-3 |