The human HOXA9 protein uses paralog-specific residues of the homeodomain to interact with TALE-class cofactors

HOX proteins interact with PBX and MEIS cofactors, which belong to the TALE-class of homeodomain (HD)-containing transcription factors. Although the formation of HOX-PBX complexes depends on a unique conserved HOX motif called hexapeptide (HX), the additional presence of MEIS induces a remodeling of...

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Detalles Bibliográficos
Autores principales: Dard, Amélie, Jia, Yunlong, Reboulet, Jonathan, Bleicher, Françoise, Lavau, Catherine, Merabet, Samir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450960/
https://www.ncbi.nlm.nih.gov/pubmed/30952900
http://dx.doi.org/10.1038/s41598-019-42096-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450960/
https://www.ncbi.nlm.nih.gov/pubmed/30952900
http://dx.doi.org/10.1038/s41598-019-42096-y

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