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Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks
DNA double-strand break (DSB) signaling and repair are critical for genome integrity. They rely on highly coordinated processes including posttranslational modifications of proteins. Here we show that Pellino1 (Peli1) is a DSB-responsive ubiquitin ligase required for the accumulation of DNA damage r...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450972/ https://www.ncbi.nlm.nih.gov/pubmed/30952868 http://dx.doi.org/10.1038/s41467-019-09641-9 |