A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition

4,6-Diamino-5-formamidopyrimidine (Fapy•dG) is an abundant form of oxidative DNA damage that is mutagenic and contributes to the pathogenesis of human disease. When Fapy•dG is in its nucleotide triphosphate form, Fapy•dGTP, it is inefficiently cleansed from the nucleotide pool by the responsible enz...

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Detalles Bibliográficos
Autores principales: Smith, Mallory R, Shock, David D, Beard, William A, Greenberg, Marc M, Freudenthal, Bret D, Wilson, Samuel H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451102/
https://www.ncbi.nlm.nih.gov/pubmed/30649431
http://dx.doi.org/10.1093/nar/gkz002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451102/
https://www.ncbi.nlm.nih.gov/pubmed/30649431
http://dx.doi.org/10.1093/nar/gkz002

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