Broad range of missense error frequencies in cellular proteins

Assessment of the fidelity of gene expression is crucial to understand cell homeostasis. Here we present a highly sensitive method for the systematic Quantification of Rare Amino acid Substitutions (QRAS) using absolute quantification by targeted mass spectrometry after chromatographic enrichment of...

Descripción completa

Detalles Bibliográficos
Autores principales: Garofalo, Raffaella, Wohlgemuth, Ingo, Pearson, Michael, Lenz, Christof, Urlaub, Henning, Rodnina, Marina V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451103/
https://www.ncbi.nlm.nih.gov/pubmed/30649420
http://dx.doi.org/10.1093/nar/gky1319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451103/
https://www.ncbi.nlm.nih.gov/pubmed/30649420
http://dx.doi.org/10.1093/nar/gky1319

Ejemplares similares