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Broad range of missense error frequencies in cellular proteins

Assessment of the fidelity of gene expression is crucial to understand cell homeostasis. Here we present a highly sensitive method for the systematic Quantification of Rare Amino acid Substitutions (QRAS) using absolute quantification by targeted mass spectrometry after chromatographic enrichment of...

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Detalles Bibliográficos
Autores principales:	Garofalo, Raffaella, Wohlgemuth, Ingo, Pearson, Michael, Lenz, Christof, Urlaub, Henning, Rodnina, Marina V
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451103/ https://www.ncbi.nlm.nih.gov/pubmed/30649420 http://dx.doi.org/10.1093/nar/gky1319

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