Structural insights reveal the specific recognition of roX RNA by the dsRNA-binding domains of the RNA helicase MLE and its indispensable role in dosage compensation in Drosophila

In Drosophila, dosage compensation globally upregulates the expression of genes located on male single X-chromosome. Maleless (MLE) helicase plays an essential role to incorporate the roX lncRNA into the dosage compensation complex (MSL-DCC), and such function is essentially dependent on its dsRNA-b...

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Detalles Bibliográficos
Autores principales: Lv, Mengqi, Yao, Yixiang, Li, Fudong, Xu, Ling, Yang, Lingna, Gong, Qingguo, Xu, Yong-Zhen, Shi, Yunyu, Fan, Yu-Jie, Tang, Yajun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451107/
https://www.ncbi.nlm.nih.gov/pubmed/30649456
http://dx.doi.org/10.1093/nar/gky1308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451107/
https://www.ncbi.nlm.nih.gov/pubmed/30649456
http://dx.doi.org/10.1093/nar/gky1308

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