Long noncoding RNA MALAT1 releases epigenetic silencing of HIV-1 replication by displacing the polycomb repressive complex 2 from binding to the LTR promoter

Long noncoding RNAs (lncRNAs) may either repress or activate HIV-1 replication and latency; however, specific mechanisms for their action are not always clear. In HIV-1 infected CD4(+) T cells, we performed RNA-Sequencing (RNA-Seq) analysis and discovered an up-regulation of MALAT1 (metastasis-assoc...

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Detalles Bibliográficos
Autores principales: Qu, Di, Sun, Wei-Wei, Li, Li, Ma, Li, Sun, Li, Jin, Xia, Li, Taisheng, Hou, Wei, Wang, Jian-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451131/
https://www.ncbi.nlm.nih.gov/pubmed/30788509
http://dx.doi.org/10.1093/nar/gkz117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451131/
https://www.ncbi.nlm.nih.gov/pubmed/30788509
http://dx.doi.org/10.1093/nar/gkz117

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