Competition between mobile genetic elements drives optimization of a phage-encoded CRISPR-Cas system: insights from a natural arms race

CRISPR-Cas systems function as adaptive immune systems by acquiring nucleotide sequences called spacers that mediate sequence-specific defence against competitors. Uniquely, the phage ICP1 encodes a Type I-F CRISPR-Cas system that is deployed to target and overcome PLE, a mobile genetic element with...

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Detalles Bibliográficos
Autores principales: McKitterick, Amelia C., LeGault, Kristen N., Angermeyer, Angus, Alam, Munirul, Seed, Kimberley D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452262/
https://www.ncbi.nlm.nih.gov/pubmed/30905288
http://dx.doi.org/10.1098/rstb.2018.0089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452262/
https://www.ncbi.nlm.nih.gov/pubmed/30905288
http://dx.doi.org/10.1098/rstb.2018.0089

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