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Competition between mobile genetic elements drives optimization of a phage-encoded CRISPR-Cas system: insights from a natural arms race
CRISPR-Cas systems function as adaptive immune systems by acquiring nucleotide sequences called spacers that mediate sequence-specific defence against competitors. Uniquely, the phage ICP1 encodes a Type I-F CRISPR-Cas system that is deployed to target and overcome PLE, a mobile genetic element with...
Autores principales: | McKitterick, Amelia C., LeGault, Kristen N., Angermeyer, Angus, Alam, Munirul, Seed, Kimberley D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452262/ https://www.ncbi.nlm.nih.gov/pubmed/30905288 http://dx.doi.org/10.1098/rstb.2018.0089 |
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