Revealing the mechanism of how cardiac myosin-binding protein C N-terminal fragments sensitize thin filaments for myosin binding

Cardiac muscle contraction is triggered by calcium binding to troponin. The consequent movement of tropomyosin permits myosin binding to actin, generating force. Cardiac myosin-binding protein C (cMyBP-C) plays a modulatory role in this activation process. One potential mechanism for the N-terminal...

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Detalles Bibliográficos
Autores principales: Inchingolo, Alessio V., Previs, Samantha Beck, Previs, Michael J., Warshaw, David M., Kad, Neil M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452674/
https://www.ncbi.nlm.nih.gov/pubmed/30877248
http://dx.doi.org/10.1073/pnas.1816480116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452674/
https://www.ncbi.nlm.nih.gov/pubmed/30877248
http://dx.doi.org/10.1073/pnas.1816480116

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