Biphasic and cardiomyocyte-specific IFIT activity protects cardiomyocytes from enteroviral infection

Viral myocarditis is a serious disease, commonly caused by type B coxsackieviruses (CVB). Here we show that innate immune protection against CVB3 myocarditis requires the IFIT (IFN-induced with tetratricopeptide) locus, which acts in a biphasic manner. Using IFIT locus knockout (IFITKO) cardiomyocyt...

Descripción completa

Detalles Bibliográficos
Autores principales: Kimura, Taishi, Flynn, Claudia T., Alirezaei, Mehrdad, Sen, Ganes C., Whitton, J. Lindsay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453442/
https://www.ncbi.nlm.nih.gov/pubmed/30958867
http://dx.doi.org/10.1371/journal.ppat.1007674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453442/
https://www.ncbi.nlm.nih.gov/pubmed/30958867
http://dx.doi.org/10.1371/journal.ppat.1007674

Ejemplares similares